Endocrine Abstracts

Background: Radioactive iodine 131I (RAI) treatment is an effective definitive treatment of hyperthyroidism, used as a first line or second line treatment.Aims and objectives1. To evaluate the response of RAI therapy in Graves’ disease.2. To determine any factors predicting treatment failure.Study design: Retrospective study: Materials and methods: Clinical ...

Introduction: Childhood cancer survivors (CCS) are at risk of vitamin D (VitD) deficiency because of chronic ill health and advice to limit sunlight exposure. Studies have demonstrated associations between VitD deficiency and cardiovascular disease. Some CCS has increased risk of cardiovascular morbidity, but data on VitD status are limited.Aim: To evaluate VitD status in CCS.Method: We compared VitD levels in CCS (n=83 (M=4...

A 65 year old female presented to ER with progressive massive lower limb oedema and dyspnea on mild exertion of insidious onset. The patient started to complain of progressive lower limb oedema shortly after her discharge from Hospital ICU in June 2020 where she was being treated for severe COVID-19. She presented then with acute kidney injury, generalized oedema and was diagnosed with COVID-19 based on clinical, laboratory criteria, PCR, and CT findings. She is a known patien...

Introduction: Pseudo Cushing syndrome (PCS) is caused by non-neoplastic over activity of the hypothalamic-pituitary-adrenal axis. Differentiating between PCS and Cushing disease (CD) can be challenging because of their overlapping clinical and biochemical features.Case presentation: 15 year old male presenting with watery diarrhea of 2 months duration occurring 3 times per day with lower limb weakness No rectal bleeding, fever, or weight loss<p class...

Glycogen Hepatopathy (GH) was initially described in 1930 by Pierre Mauriac. 90 years later, GH remains underrecognized in adults. The clinical or radiological characterization of GH is difficult, further compounded by lack of widespread literature. We present two cases of GH characterized by recurrent lactatemia and transient liver function and radiological abnormalities.• 19 years old male with Type 1 diabetes admitted with nausea and vomiting. pH...

The hormonally active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) acting via the vitamin D receptor (VDR) is a potent transcriptional regulator, with effects on skeletal and extra-skeletal physiology. We have shown previously that skeletal responses to 1,25D also involve regulation of microRNAs (miRNAs); small non-coding RNAs with an emerging role in epigenetics. To assess the role of miRNAs in innate immune responses to 1,25D we utilised in v...

The hormonally active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) acting via the vitamin D receptor (VDR) is a potent transcriptional regulator, with effects on skeletal and extra-skeletal physiology. We have shown previously that skeletal responses to 1,25D also involve regulation of microRNAs (miRNAs); small non-coding RNAs with an emerging role in epigenetics. To assess the role of miRNAs in innate immune responses to 1,25D we utilised in v...

Aim: To investigate the volumetric changes in cortical and subcortical deep gray matter (GM) structures and cognitive alterations in patients with mild autonomous cortisol secretion (MACS). We also sought to assess whether the anticipated changes in brain volume and cognitive functions of the patients with MACS differ from the changes in patients with overt Cushing’s Syndrome (CS). Methods: In this cross-sectional study, volumes of the cortex, hippo...

A 71 year lady, who has past history of acute ischaemic stroke ( now bed bound and can only get out of bed with the help of a hoist) , Type 2 diabetes melitus, HTN, CKD and high lipid. She is on Metformin 1 gm twice daily, Ramipril 5 mg at night, Clopidogrel 75 mg od, Atorvastatin 80 mg od. She was brought to hospital by unexplained drowsiness and poor oral intake. Her blood sugar was 72, ketone 5.2, Ph: 7.21, Na: 165, Urea 14 and calculated osmolality of 412. Her chest xray a...

We describe a case of 31 year young lady with Type 1 Diabetes, who started experiencing reduction in insulin requirement and hypoglycaemia episodes due to an endocrine disorder following Pregnancy. She presented with recurrent episodes of documented hypoglycaemia and amenorrhea following successful pregnancy. Her basal insulin requirements fell from 36 units to 24 units per day and she required little if any insulin as bolus (0.5 unit for every 10 gm). She did not breast feed....